The second season of Ani ni Tsukeru Kusuri wa Nai!. 
 
As always, Shi Miao is tired of her brother's ridiculous antics, and Shi Fen can only hope to escape the clutches of his violent sister. With their friends and classmates in tow, the two continue their dysfunctional relationship as reluctant but devoted siblings. 
 
Note: Airing dates reflect the original airing and premiere dates in China, where it aired earlier than it did in Japan.