After human experimentation turns Kisaragi into a cyborg, he finds himself pursued by multiple organizations: An undying coven of vampires bent on the conquest of Tokyo, and an immortal order of Knights, and a group of Yakuza, sworn to avenge the killing of their leader. 
"I might not have any reason to live, but that's no reason to let them kill me." 
Kisaragi will have to use his cyborg-body and his unique "blood", as well as anything else he can to make his big escape!!! 
(Source: Polygon Pictures)